500彩票网

Now that the total number of individuals with dementia in Japan exceeds five million, research and development of strategies for prevention and therapeutics of Alzheimer’s disease (AD) are urgent issues. Our project aims to promote research on elucidating the mechanisms of disorders leading to dementia and development of therapies at the very early stage of AD, thereby addressing various problems with dementia and establishing a healthy aging society.

- University of Southern California
- Harvard University
- National Center for Neurology and Psychiatry
- National Center for Geriatrics and Gerontology
- Tohoku University
- Osaka University

- Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T: The role of presenilin cofactors in the γ-secretase complex. Nature 422:438-441, 2003
- Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H, Sun CK, Beckett LA, Petersen RC, Weiner MW, Aisen PS, Donohue MC: Japanese and North American Alzheimer’s Disease Neuroimaging Initiative studies: harmonization for international trials. Alzheimers Dementia 14:1077-1087, 2018
- Eguchi T, Kuwahara T, Sakurai M, Komori T, Fujimoto T, Ito G, Yoshimura SI, Harada A, Fukuda M, Koike M, Iwatsubo T: LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis. Proc Natl Acad Sci USA 115:E9115-E9124, 2018